Revolutionizing Tissue Ablation in ENT

Irreversible Electroporation (IRE / PFA) is delivered through a bipolar handpiece using ultra-short electrical pulses that trigger delayed cell apoptosis, resulting in the ablation of soft tissue.

ENTire Medical Device in Clinical Setting

Our Tech

Ablation of Tonsillar Hypertrophy
with the ENTIRE IRE System

The ENTire IRE System utilizes advanced Irreversible Electroporation (IRE) technology to deliver short-duration, high-voltage electrical pulses that create targeted tissue ablation with no bleeding.

Ablation of Inferior Turbinate Hypertrophy

Enables precise submucosal tissue ablation while preserving the mucosa and minimizing post-procedural inflammation.

Advantages

Key clinical benefits of the ENTIRE IRE system

Non Invasive

No Bleeding

Minimal Pain

No Thermal Damage

Minimal Inflammation

Short Procedure

Fast Recovery

Improved Wound Healing

Procedure Overview

FDA Cleared | Rx Only

Adult Tonsillar Hypertrophy

Adult Tonsillar
Hypertrophy

Pediatric Adenotonsillar Hypertrophy

Pediatric Adenotonsillar
Hypertrophy

Inferior Turbinate Hypertrophy

Inferior Turbinate
Hypertrophy

System Components

Catalog Number
System Components
Electrode L×W (mm)
ENTIRE001
ENTIRE Generator
——
ENTCON01S
ENTIRE Nasal Handpiece
8 × 2.2
ENTTON01SSSmall
ENTTON01SMMedium
ENTTON01SLLarge
ENTIRE Tonsil Handpiece
6 × 4.58.5 × 4.511.5 × 4.5

Tonsil Handpiece

Nasal Handpiece

A New Standard in
Tissue Ablation

Short, non-invasive and painless procedure

Targeted tissue ablation while preserving the mucosa with minimal impact

Bloodless with no thermal tissue damage

Fast recovery

ENTire Medical Device System

News & Events

SCIENTIFIC PUBLICATION

July 2026

Clinical Study of IRE for Tonsillar Ablation in Children

ENTIRE's clinical study on Irreversible Electroporation (IRE) for the treatment of pediatric enlarged tonsils has been published in the Journal of Clinical Medicine. This peer-reviewed publication presents the clinical outcomes of ENTIRE's minimally invasive technology, supporting its safety and feasibility for the treatment of enlarged tonsils in children.

Published in: Journal of Clinical Medicine (MDPI)

SCIENTIFIC PUBLICATION

April 2026

First Clinical Study of IRE for Tonsillar Ablation in Adults

The study, published in Otolaryngology–Head and Neck Surgery, presents the clinical outcomes of ENTIRE's Irreversible Electroporation (IRE) technology for tonsillar ablation in adults.

Published in: Otolaryngology–Head and Neck Surgery

Combined Otolaryngology Spring Meetings (COSM) 2026

ASPO Annual Meeting – Quickshot Oral Presentation

ENTire's research on Irreversible Electroporation for the treatment of pediatric adenotonsillar hypertrophy has been selected for a Quickshot oral presentation at the ASPO Annual Meeting during COSM 2026.

Friday, April 24, 2026 | 3:50 PM

Presented by: Ari DeRowe, MD

Combined Otolaryngology Spring Meetings (COSM) 2026

ARS Annual Meeting

ENTire's research on Irreversible Electroporation for the treatment of inferior turbinate hypertrophy has been accepted for presentation at the ARS Annual Meeting during COSM 2026.

Saturday, April 25, 2026 | 10:40 AM

Presented by: Narin Carmel Niederman, MD

FULL SCIENTIFIC PAPER

October 12, 2025

Scientific Oral Presentation at AAO-HNS 2025

Irreversible Electroporation for Tonsillar Ablation in Adults was presented during the Scientific Oral Presentations – Comprehensive Otolaryngology session. The prospective clinical study demonstrated no intra- or postoperative bleeding, procedure times under 5 minutes, and significant reduction in tonsillar size and symptom scores at 3-month follow-up.

Presented by: Ari DeRowe, MD

FAQ

Common questions about our technology

Adult Tonsillar Hypertrophy

Adult Tonsillar Hypertrophy

The procedure is typically completed within a few minutes.

Performed under sedation or general anesthesia.

Patients typically experience minimal downtime, with most returning to normal activities the same day or the following day. Mild, temporary discomfort may occur for up to two weeks after the procedure.

Most patients report minimal discomfort, which can be managed with additional anesthesia.

Bleeding is not expected during or after the procedure.

Pediatric Adenotonsillar Hypertrophy

Pediatric Adenotonsillar Hypertrophy

Completed within a few minutes.

The procedure is performed under general anesthesia.

Children typically recover quickly once the effects of the anesthesia wear off, with a rapid return to regular activities.

Children typically experience little to no pain, with mild discomfort manageable with additional anesthesia.

Bleeding is not expected during or after the procedure.

Inferior Turbinate Hypertrophy

Inferior Turbinate Hypertrophy

The procedure is typically completed in approximately 5 minutes.

The procedure is performed under local or topical anesthesia, based on patient comfort and clinical need.

Patients typically return to normal activities within hours, once the effects of the anesthesia wear off.

Most patients report little to no pain, with only mild discomfort that can be managed with additional anesthesia.

Bleeding is not expected during or after the procedure.

Contact

United States Office

903 N. Bowser Rd. Ste. 330
Richardson, TX 75081
USA

Toll Free: 1-800-408-0120Tel: +1-901-850-1337

Email: info@ent-ire.com

Israel Office

11 Ha'hoshlim St.
Herzeliya 4672411
Israel

Tel: +972-9-951-1511

Email: info@ent-ire.com